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September 1, 1998HypertensionOpen Access

Endothelial Nitric Oxide Synthase Gene Polymorphism and Acute Myocardial Infarction

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Why the study?

Are endothelial nitric oxide synthase (eNOS) gene polymorphisms associated with an increased risk of acute myocardial infarction?

Population

226 patients with acute myocardial infarction (AMI) and 357 healthy gender- and age-matched control subjects

Comparison

Presence of endothelial nitric oxide synthase… vs Absence of these polymorphisms

Design

Case-control

Authors

KHKiyoshi HibiInterventional CardiologyTITomoaki IshigamiGeneral CardiologyKTKouichi TamuraGeneral Cardiology

Discussion

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Implication

May support eNOS polymorphism as AMI risk factor independent of atherosclerosis; hypothesis-generating and should not yet change practice.

Structured PICO

Are endothelial nitric oxide synthase (eNOS) gene polymorphisms associated with an increased risk of acute myocardial infarction?

P
Population
226 patients with acute myocardial infarction (AMI) and 357 healthy gender- and age-matched control subjects
I
Intervention
Presence of endothelial nitric oxide synthase (eNOS) gene polymorphisms (Glu-Asp298 and 4a/b)
C
Comparator
Absence of these polymorphisms (or different genotypes)
O
Outcome
Risk of acute myocardial infarction (AMI)hard clinical

Homozygosity for the Glu-Asp298 polymorphism in the eNOS gene may genetically predispose individuals to acute myocardial infarction, independent of coronary atherosclerosis severity.

Cite This Study

Hibi et al. (1998) studied this question.

synapsesocial.com/papers/6a76874ab23aadda25c44ef6https://doi.org/10.1161/01.hyp.32.3.521

Topics

Coronary artery disease
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Molecular Variant of Angiotensinogen Gene Is Associated With Coronary Atherosclerosis1995 · 118 citations
  2. 2Angiotensin-Converting Enzyme Gene Polymorphism Adds Risk for the Severity of Coronary Atherosclerosis in Smokers1997 · 31 citations
  3. 3Lack of Evidence for Linkage of the Endothelial Cell Nitric Oxide Synthase Gene to Essential Hypertension1995 · 162 citations
  4. 4Nitric Oxide Activity Is Deficient in Spasm Arteries of Patients With Coronary Spastic Angina1996 · 384 citations