What question did this study set out to answer?

To compare the patterns of drug-resistant point mutations associated with antiretroviral treatment failure between HIV-1 subtype B and CRF01_AE (subtype E) infections.

July 1, 2003JAIDS Journal of Acquired Immune Deficiency Syndromes

Patterns of Point Mutations Associated With Antiretroviral Drug Treatment Failure in CRF01_AE (Subtype E) Infection Differ From Subtype B Infection

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To compare the patterns of drug-resistant point mutations associated with antiretroviral treatment failure between HIV-1 subtype B and CRF01_AE (subtype E) infections.
Conducted a cross-sectional study analyzing protease and C2V3 sequence data from 216 sexually infected patients with detectable plasma HIV-1 RNA in Japan.
Used phylogenetic analysis to classify viral subtypes, identifying 162 subtype B and 45 CRF01_AE infections.
Assessed mutation profiles among patients experiencing treatment failure with nucleoside reverse transcriptase inhibitors (82 subtype B, 24 CRF01_AE) or protease inhibitors (69 subtype B, 19 CRF01_AE).
The reverse transcriptase mutations T69N and V75M, along with protease mutations L10F, K20I, L33I, and N88S, occurred more frequently in CRF01_AE infections than in subtype B infections.
Protease mutations D30N, A71V, and N88D occurred exclusively in patients infected with subtype B.
Most characteristic resistance mutation differences between the subtypes were linked to prior exposure to the protease inhibitor nelfinavir.

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Implication

Cross-sectional study uncovers distinct drug resistance mutations between HIV-1 CRF01_AE and subtype B infections, suggesting subtype B resistance data may not generalize to non-B subtypes.

Cite This Study

Ariyoshi et al. (2003) studied this question.

synapsesocial.com/papers/6a95bf388d5c74f8bd333369 https://doi.org/10.1097/00126334-200307010-00007

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Implication

Cross-sectional study uncovers distinct drug resistance mutations between HIV-1 CRF01_AE and subtype B infections, suggesting subtype B resistance data may not generalize to non-B subtypes.

Patterns of Point Mutations Associated With Antiretroviral Drug Treatment Failure in CRF01_AE (Subtype E) Infection Differ From Subtype B Infection

Key Points

Discussion

Implication

Cite This Study

Patterns of Point Mutations Associated With Antiretroviral Drug Treatment Failure in CRF01_AE (Subtype E) Infection Differ From Subtype B Infection

Key Points

Discussion

Implication

Cite This Study

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