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June 10, 1996FEBS Letters

Immunolocalization of an inwardly rectifying K+ channel, KAB‐2 (Kir4.1), in the basolateral membrane of renal distal tubular epithelia

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Population

Rat kidney tissue

Design

Preclinical

Authors

MIMinoru ItoNara Institute of Science and TechnologyAIAtsushi InanobeThe University of OsakaYHYoshiyuki HorioSapporo Medical University

Discussion

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Overview

K(AB)-2 emerges as candidate basolateral K+ channel in distal tubules; leaves open its role in epithelial Na+-K+ transport.

Structured PICO

P
Population
Rat kidney tissue
I
Intervention
Immunohistochemical staining with affinity-purified anti-K(AB)-2 antibody
O
Outcome
Localization of K(AB)-2 immunoreactivitysurrogate

Identifies K(AB)-2 as the first K+ channel localized in the basolateral membrane of renal epithelia, potentially contributing to Na+-K+ pump function.

Cite This Study

Ito et al. (1996) studied this question.

synapsesocial.com/papers/6a95bfa748cc82301f33320ehttps://doi.org/10.1016/0014-5793(96)00502-9
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  4. 4Electrophysiological identification of alpha- and beta-intercalated cells and their distribution along the rabbit distal nephron segments.1990 · 102 citations
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