The localization of prorenin in the ciliary epithelium supports its role in a putative ocular renin-angiotensin system.
Supports ocular renin-angiotensin system in animals; leaves open human relevance and clinical implications.
Prorenin (PR) was localized by electron microscopic (EM) immunostaining of cryo-ultramicrotomy sections of human ciliary body and correlated with light microscopic immunostaining. Both layers of the ciliary epithelium contained the prohormone. However, density was much higher in the adjacent extracellular spaces, particularly in the vitreous cortex. This observation adds further evidence to a role of the ciliary epithelium in the transfer, storage or synthesis of components of a putative ocular renin angiotensin system.
No takes yet. Share an insight, caveat, or question.
Wallow et al. (1993) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:
More from Current Eye Research