Key result
Female patients undergoing isolated CABG had higher 30-day mortality than males (1.4% vs 0.6%, p=0.017), but male gender was independently associated with lower long-term survival (p=0.0037).
Why the study?
To assess short- and long-term survival after isolated CABG, evaluate the impact of gender and age, and compare long-term survival with the general population.
How do gender and age impact short- and long-term survival in patients undergoing isolated CABG compared to each other and the general population?
Cohort (n=4,044)
No
How do gender and age impact short- and long-term survival in patients undergoing isolated CABG compared to each other and the general population?
Absolute Event Rate: 1.4% vs 0.6%
p-value: p=0.017
Following isolated CABG, females have higher 30-day mortality but better adjusted long-term survival compared to males, while males under 60 have worse long-term survival than the general population.
Short-term mortality risk in females warrants attention; leaves open validation of long-term gender effects in prospective studies.
Objectives. Assess the short- and long-term survival for patients who underwent isolated coronary artery bypass grafting (CABG) and evaluate the impact of gender and age. Furthermore to assess the long-term survival in the CABG group compared to the general population. Design. This study included 4044 consecutive patients who underwent isolated CABG at Oslo University Hospital, Ullevål, in Oslo, Norway in the time period from 01 January 2003 to 31 December 2015. Patient data was collected retrospectively from the quality register at the department. Information on survival status was obtained from the Norwegian National Registry. Life expectancy data for the general population was gained from Statistics Norway. Results. Female patients were significantly older than male patients at the time of surgery (mean age 67.0 and 63.9 years, respectively, p < .001), and had significantly lower 30-day survival (mortality was 1.4% and 0.6%, respectively, p = .017). Male gender was independently associated with lower long-term survival (p = .0037) in a multivariate analysis. Male patients aged less than 60 years also showed significantly lower long-term survival (SMR = 1.84, 95% CI = 1.49–2.25) compared to the age-matched general population. Among patients older than 60 years, survival was similar to survival in the age-matched general population. Conclusions. Survival was excellent for patients undergoing surgery. Despite increased age and operative mortality, female patients had better adjusted long-time survival than male patients. There was lower long-term survival among male patients aged less than 60 compared to the general population. Our findings may help clinicians in selecting appropriate patients for surgery.
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Weltzien et al. (2019) conducted a cohort in Isolated coronary artery bypass grafting (CABG) (n=4,044). Female gender vs. Male gender was evaluated on 30-day mortality (p=0.017). Female patients undergoing isolated CABG had higher 30-day mortality than males (1.4% vs 0.6%, p=0.017), but male gender was independently associated with lower long-term survival (p=0.0037).
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