What is the clinical evidence from this study?

Population: Myocardial infarction (n=26). Intervention: Telmisartan vs. Saline control. Primary outcome: Pathological remodeling (end-diastolic left ventricular diameter, ventricular septum thickness, myocardial fibrosis).

May 4, 2012Journal of Cardiovascular Pharmacology

Different Roles of PPAR-γ Activity on Physiological and Pathological Alteration After Myocardial Ischemia

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Key result

Telmisartan suppressed pathological remodeling and myocardial fibrosis in rats with myocardial infarction via PPAR-γ agonistic activities, independent of its antihypertensive effects.

Why the study?

Does telmisartan suppress pathological remodeling after myocardial ischemia in a rat model?

Structured PICO

Does telmisartan suppress pathological remodeling after myocardial ischemia in a rat model?

Population

26 rats with induced myocardial infarction assigned to control, telmisartan, telmisartan + GW9662, or amlodipine.

Intervention

Telmisartan (10 mg/kg/d), telmisartan + GW9662 (PPAR-γ-antagonist) (10 mg/kg/d + 1 mg/kg/d), or amlodipine (10 mg/kg/d)

Comparator

Saline control

Outcome

End-diastolic left ventricular diameter, ventricular septum thickness, and myocardial fibrosissurrogate

Telmisartan suppresses pathological remodeling after myocardial infarction through PPAR-γ agonistic activities, independent of its blood pressure-lowering effects.

Discussion

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Implication

Telmisartan may attenuate post-MI remodeling via PPAR-γ in rats; leaves open translation to human therapy pending clinical trials.

Cite This Study

Nagashima et al. (2012) studied Myocardial infarction (n=26). Telmisartan vs. Saline control was evaluated on Pathological remodeling (end-diastolic left ventricular diameter, ventricular septum thickness, myocardial fibrosis). Telmisartan suppressed pathological remodeling and myocardial fibrosis in rats with myocardial infarction via PPAR-γ agonistic activities, independent of its antihypertensive effects.

synapsesocial.com/papers/6a95c1f5223f4b595a4f0df5 https://doi.org/10.1097/fjc.0b013e3182592d7b

View Full Paper

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Different Roles of PPAR-γ Activity on Physiological and Pathological Alteration After Myocardial Ischemia

Structured PICO

Discussion

Implication

Cite This Study

Different Roles of PPAR-γ Activity on Physiological and Pathological Alteration After Myocardial Ischemia

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider