Key result
Adenosine deaminase acting on RNA (ADAR) catalyzes A-to-I editing in double-stranded RNA, altering the sequence and base pairing of protein-coding and non-coding RNAs with wide physiological effects.
Design
Review
Authors
Loading...
Broad ADAR effects in RNA merit cardiovascular disease exploration; leaves open clinical translation of editing modulators.
Provides an overview of how ADAR-mediated A-to-I RNA editing affects protein-coding and non-coding RNAs in physiological and disease states.
Mallela et al. (2012) reported a review. A-to-I RNA editing by ADAR was evaluated. Adenosine deaminase acting on RNA (ADAR) catalyzes A-to-I editing in double-stranded RNA, altering the sequence and base pairing of protein-coding and non-coding RNAs with wide physiological effects.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: