Key result
Fluid overload in patients with anasarca significantly attenuated the sum of P wave amplitudes from 10.5 mm at admission to 3.8 mm at peak weight (P=0.0005).
Why the study?
Do changing edematous states alter P wave amplitude on ECG in patients with anasarca or undergoing hemodialysis?
Observational (n=57)
Do changing edematous states alter P wave amplitude on ECG in patients with anasarca or undergoing hemodialysis?
Absolute Event Rate: 3.8% vs 10.5%
p-value: p=0.0005
Fluid overload significantly attenuates P wave amplitudes on ECG, indicating that accurate measurement of P wave amplitudes requires alleviation of fluid overload.
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Fluid overload warrants caution in P-wave amplitude interpretation on ECG; this Level 3 cohort study leaves open whether edema correction improves diagnostic accuracy.
John E. Madias (2004) conducted an observational in Anasarca and changing edematous states (n=57). Changing edematous states (anasarca or hemodialysis) vs. Baseline (admission) or controls without weight change was evaluated on Sum of P wave amplitude in millimeters measured in the 12 leads of the ECG (SigmaP) (p=0.0005). Fluid overload in patients with anasarca significantly attenuated the sum of P wave amplitudes from 10.5 mm at admission to 3.8 mm at peak weight (P=0.0005).
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