Key result
Hemodialysis was associated with significantly increased P-wave duration and reduced late potentials of the P wave compared to controls (P<0.05).
Why the study?
Does hemodialysis alter P-wave signal-averaged electrocardiogram parameters in patients?
Observational (n=159)
Does hemodialysis alter P-wave signal-averaged electrocardiogram parameters in patients?
p-value: p=<0.05
Hemodialysis acutely alters P-wave signal-averaged ECG parameters, which may have implications for atrial fibrillation risk assessment in this population.
May warrant timing-aware AF risk assessment in hemodialysis; leaves open prospective validation for arrhythmia prediction.
The role of P-wave signal-averaged electrocardiography (P-SAECG) in the prediction of atrial fibrillation (AF) attacks has been validated in various disease states. In the present study, we aimed to investigate the effect of hemodialysis (HD) on P-SAECG parameters and to determine the related risk factors that might affect those parameters. Ninety-one HD patients and 68 controls were included. Hemoglobin levels, serum electrolytes, arterial pH, and interdialytic weight changes were assessed. P-wave duration (PWD) and late potentials of P wave (root-mean-square voltage for the last 20 ms of the signal-averaged P wave [LP20]) were determined by P-SAECG. Pre- and postdialysis PWDs were significantly increased in HD patients than in controls (both P < 0.05), while the voltages of pre- and postdialysis LP20 were significantly reduced (both P < 0.05). A significant increase in PWD (P < 0.05) and a significant decrease in LP20 (P < 0.05) were observed following HD. Pre- and postdialysis PWDs and LP20 were correlated with age (all P < 0.05), dialysis duration (all P < 0.05), and left atrial diameters (LADs) (pre- and postdialysis) (all P < 0.05). Intradialytic changes in serum potassium levels were only correlated with postdialysis PWD and LP20 in HD patients (both P < 0.05). HD seems to increase PWD and to reduce LP20. Advanced age, duration of HD, intradialytic change in serum potassium levels, and LAD seem to be the important associates of P-SAECG parameters in HD patients.
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Özcan et al. (2007) conducted an observational in Hemodialysis (n=159). Hemodialysis vs. Controls was evaluated on P-wave duration (PWD) and late potentials of P wave (LP20) (p=<0.05). Hemodialysis was associated with significantly increased P-wave duration and reduced late potentials of the P wave compared to controls (P<0.05).
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