Key result
Combination therapy with clopidogrel and rivaroxaban resulted in complete resolution of right atrial thrombosis in all three dogs and appeared safe and well tolerated.
Why the study?
Does combination therapy with clopidogrel and rivaroxaban resolve secondary right atrial thrombosis in dogs?
Case Report (n=3)
Does combination therapy with clopidogrel and rivaroxaban resolve secondary right atrial thrombosis in dogs?
Combination therapy with clopidogrel and rivaroxaban safely and effectively resolved secondary right atrial thrombosis in a small case series of dogs.
Echocardiographic irregular margins with hypoechoic regions may suggest right atrial thrombus in dogs with systemic disease; small cohort leaves generalizability open.
Three dogs were diagnosed with right atrial thrombosis, thought to be secondary to systemic diseases. Specifically, two cases had hyperadrenocorticism and one case was diagnosed with pancreatitis with acute renal injury. In all cases, the thrombi were found within the right atrium, necessitating a differentiation from cardiac neoplasia. In all three cases, the structures assumed to be thrombi had irregular margins with interspersed hypoechoic regions, which were later confirmed as thrombi based on the responsiveness to therapy. All three cases were prescribed with the combination of clopidogrel and rivaroxaban.The thrombi gradually disappeared after initiation of the combination therapy. Complete resolution of right atrial thrombosis was noted in each dog treated with clopidogrel and rivaroxaban. This combination therapy appears to be safe and well tolerated. Diligent observation of the echocardiographic findings and clinical course allows the diagnosis of thrombosis.
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Yoshida et al. (2023) conducted a case report in Right atrial thrombosis (n=3). Clopidogrel and rivaroxaban was evaluated on Resolution of right atrial thrombosis. Combination therapy with clopidogrel and rivaroxaban resulted in complete resolution of right atrial thrombosis in all three dogs and appeared safe and well tolerated.
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