Population
Rabbits (n=25; 5 per time point for 4 time points, plus 5 nonimmobilized controls)
Comparison
Immobilization of the right hindlimb knee in… vs Nonimmobilized left hindlimb and nonimmobilized…
Design
Preclinical
Follow-up
up to 48-72 hours
Authors
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Early muscle damage risk warrants minimized immobilization; leaves open translation from rabbit models to clinical practice.
Immobilization of rabbit skeletal muscle rapidly induces transient mitochondrial abnormalities, CK efflux, and progressive myofibrillar damage, indicating early metabolic disturbance.
Leivo et al. (1998) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: