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ONE of the many major difficulties encountered in the synthesis of tryptophan is that connected with the preparation ofthe parent substance, indole-3-aldehyde. Despite the exceedingly poor yields which Ellinger The only one, indeed, worthy of mention is that of Majima and The method, whilst it gives a primary yield of aldehyde higher than that obtained by Ellinger, suffers from the drawback that it is not applicable
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Boyd et al. (1935) studied this question.
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