March 1, 1994European Heart Journal
Chrome congestive heart failure
Why the study?
Does the addition of atropine compensate for the presence of beta-blockers in detecting wall motion abnormalities during dobutamine stress echocardiography in patients evaluated for chest pain?
Population
26 patients referred for evaluation of chest pain
Comparison
Dobutamine stress echocardiography with the… vs Dobutamine stress echocardiography with the…
Design
RCT, random order sequence
Authors
Discussion
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Member takes
Implication
Supports adding atropine to dobutamine stress echocardiography in beta-blocked patients; confirms restored wall motion abnormality detection rates.
Structured PICO
Does the addition of atropine compensate for the presence of beta-blockers in detecting wall motion abnormalities during dobutamine stress echocardiography in patients evaluated for chest pain?
P
Population
26 patients referred for evaluation of chest pain
I
Intervention
Dobutamine stress echocardiography (up to 40 micrograms/kg/min) with the addition of atropine (to achieve 85% of age-predicted maximal heart rate) while on metoprolol 100 mg b.i.d.
C
Comparator
Dobutamine stress echocardiography with the addition of atropine while off metoprolol (after a wash-out period of at least 48 h)
O
Outcome
Occurrence of new or worsened wall motion abnormalitiessurrogate
The addition of atropine during dobutamine stress echocardiography effectively compensates for the blunted ischemic response caused by beta-blocker therapy, allowing for accurate detection of wall motion abnormalities.
Cite This Study
Poldermans et al. (1994) studied this question.