Co-administration of lovastatin and warfarin can lead to a potentially serious drug interaction causing hypoprothrombinemia and bleeding, requiring diligent prothrombin time monitoring.
Suggests possible lovastatin-warfarin interaction risk; case reports leave open need for prospective confirmation before practice change.
• Two patients who developed hypoprothrombinemia and bleeding due to lovastatin-warfarin drug interaction are described. Because of the wider use of lovastatin and warfarin, heightened clinical awareness of this potentially serious interaction must be publicized. Therefore, prothrombin time should be monitored diligently when warfarin is prescribed to patients receiving lovastatin. (Arch Intern Med.1990;150:2407)
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Saeed Ahmad (1990) studied this question.
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