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Observes no change in prothrombin time or pharmacokinetics during pravastatin coadministration with oral anticoagulants, suggesting a distinct safety profile compared to other statins.
Pravastatin is a hydrophilic competitive inhibitor of 3-hydroxy-3-methyl glutaryl coenzyme A, the enzyme responsible for the rate limiting step of endogenous cholesterol synthesis. Interaction studies with oral anticoagulants have shown no change in prothrombin time or in the pharmacokinetic variables of pravastatin.1 On the other hand, when lovastatin2 or simvastatin3 and coumarin are administered concomitantly, prothrombin time may be increased in …
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Given et al. (1996) studied this question.
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