Key result
The provided text contains only journal masthead information and lacks the clinical data for the study on pravastatin.
Why the study?
Does pravastatin reduce thrombogenicity independent of cholesterol lowering in a hypercholesterolemic swine model?
Population
Swine fed a hypercholesterolemic diet for 100 days, alongside a normocholesterolemic control group.
Comparison
Pravastatin added to the hypercholesterolemic… vs Placebo added to the hypercholesterolemic diet…
Design
Preclinical, randomly assigned
Follow-up
50 days of treatment
Authors
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Hypothesis-generating for cholesterol-independent antithrombotic effects in animals; leaves open translation to human practice.
Does pravastatin reduce thrombogenicity independent of cholesterol lowering in a hypercholesterolemic swine model?
Pravastatin reduces blood thrombogenicity through mechanisms independent of plasma cholesterol lowering, supporting the pleiotropic benefits of statins in cardiovascular disease prevention.
Casaní et al. (2005) studied this question. Pravastatin was evaluated. The provided text contains only journal masthead information and lacks the clinical data for the study on pravastatin.
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