Why the study?
Does pravastatin reduce platelet activation-dependent procoagulant activity under high shear blood flow conditions in an in vitro model?
Population
In vitro perfusion chamber system using whole blood
Comparison
Pravastatin vs Atorvastatin and implied control
Design
Preclinical
Authors
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May extend statin pleiotropic effects to high-shear platelet procoagulant activity; hypothesis-generating and should not change practice.
Does pravastatin reduce platelet activation-dependent procoagulant activity under high shear blood flow conditions in an in vitro model?
Pravastatin demonstrates shear rate-dependent antithrombotic activity in vitro, offering a novel mechanistic explanation for its cardiovascular benefits.
Hamada et al. (2010) studied this question.
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