Pravastatin Decreases Blood Pressure in Hypertensive and Hypercholesterolemic Patients Receiving Antihypertensive Treatment
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Key result
Pravastatin treatment significantly reduced systolic blood pressure from 134 to 130 mmHg in hypercholesterolemic patients receiving antihypertensive treatment, but not in normotensive patients.
Why the study?
Does pravastatin reduce blood pressure in hypercholesterolemic patients receiving antihypertensive treatment?
Population
82 Japanese patients with hypercholesterolemia, mean age 62±9 years, 39 men and 43 women. 44 had…
Comparison
Pravastatin 10 mg/day orally for 3 months vs Baseline values before pravastatin treatment
Design
Cohort
Follow-up
3 months
Authors
Discussion
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Implication
May support adjunctive BP lowering with pravastatin in treated hypertensives with hypercholesterolemia; leaves open causal confirmation in RCTs.
Study Design
Type
Cohort (n=82)
Multicenter
No
Structured PICO
Does pravastatin reduce blood pressure in hypercholesterolemic patients receiving antihypertensive treatment?
P
Population
82 Japanese patients (mean age 62 years, 52.4% female) with hypercholesterolemia, including 44 on antihypertensive treatment, evaluated retrospectively before and after 3 months of pravastatin therapy.
E
Exposure
Pravastatin 10 mg/day orally for 3 months
C
Comparator
Baseline values before pravastatin treatment (retrospective before-after comparison)
O
Outcome
Change in systolic and diastolic blood pressure after 3 months of treatmentsurrogate
Main Result
Absolute Event Rate: 130% vs 134%
p-value: p=<0.005
Concomitant use of pravastatin and antihypertensive drugs may improve blood pressure control in hypertensive patients with hypercholesterolemia, particularly those with uncontrolled blood pressure.
Limitations
- Retrospective study design
- Not a randomized double-blind, placebo-controlled cross-over trial
- Placebo-like hypotensive effect of pravastatin cannot be completely excluded
- Retrospective design
- Placebo-like hypotensive effect cannot be completely excluded
Cite This Study
Kawano et al. (2006) conducted a cohort in Hypercholesterolemia and Hypertension (n=82). Pravastatin vs. Baseline (before treatment) was evaluated on Systolic blood pressure in hypertensive patients (p=<0.005). Pravastatin treatment significantly reduced systolic blood pressure from 134 to 130 mmHg in hypercholesterolemic patients receiving antihypertensive treatment, but not in normotensive patients.
Topics
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