January 1, 1994Blood Pressure
Short Term Effects of Pravastatin on Blood Pressure in Hypercholesterolaemic Hypertensive Patients
Key result
Pravastatin reduced total cholesterol by 27% (P<0.001) but did not change systolic or diastolic blood pressure in hypertensive hypercholesterolaemic patients.
Why the study?
Does pravastatin reduce blood pressure in hypertensive hypercholesterolaemic patients on background antihypertensive therapy?
Population
25 hypertensive hypercholesterolaemic patients on background antihypertensive therapy with ACE inhibitors…
Comparison
Pravastatin for 12 weeks vs Placebo for 12 weeks
Design
RCT, double blind
Follow-up
12 weeks
Authors
Discussion
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Implication
Pravastatin adds no blood pressure benefit in treated hypertensive hypercholesterolemic patients; confirms lipid lowering as its sole effect in this setting.
Study Design
Type
RCT (n=25)
Blinding
Double-blind
Structured PICO
Does pravastatin reduce blood pressure in hypertensive hypercholesterolaemic patients on background antihypertensive therapy?
P
Population
25 hypertensive hypercholesterolaemic patients on background antihypertensive therapy with ACE inhibitors and calcium antagonists, treated for 12 weeks.
I
Intervention
Pravastatin for 12 weeks
C
Comparator
Placebo for 12 weeks
O
Outcome
Changes in plasma lipids (total cholesterol and low density lipoprotein cholesterol) and blood pressure (systolic and diastolic)surrogate
Main Result
Effect estimate: 27% reduction
p-value: p=<0.001
Pravastatin effectively lowers lipids in hypertensive hypercholesterolemic patients on ACE inhibitors and calcium antagonists but does not provide additional blood pressure reduction.
Cite This Study
Oߣcallaghan et al. (1994) conducted an RCT in Hypercholesterolaemia and hypertension (n=25). Pravastatin vs. Placebo was evaluated on Total cholesterol (27% reduction, p=<0.001). Pravastatin reduced total cholesterol by 27% (P<0.001) but did not change systolic or diastolic blood pressure in hypertensive hypercholesterolaemic patients.