Key result
Subtomogram averaging of rat cardiac muscle revealed that the Z-band comprises four to six layers of links, likely α-actinin, linking antiparallel overlapping ends of actin filaments.
The study provides high-resolution 3D structural details of the rat cardiac muscle Z-band, revealing 4-6 layers of links and a terminal region likely housing CapZ.
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Rodent data offer no immediate clinical guidance; extends nanoscale Z-band models while leaving human translation open.
Burgoyne et al. (2015) studied this question. Subtomogram averaging of rat cardiac muscle revealed that the Z-band comprises four to six layers of links, likely α-actinin, linking antiparallel overlapping ends of actin filaments.
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