Plasma VEGF-D and sFLT-1 are potential biomarkers of hemodynamics and congestion in heart failure and following heart transplantation

Figures

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  Figure 1. Survival of patients with advanced heart failure at inclusion, following heart transplantation, censoring was done at 10 years of follow-up.

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  Figure 2. Plasma VEGF-D levels (a), and (b-g) repeated measures correlation analyses with multiple hemodynamic parameters before and at multiple follow-ups after heart transplantation (HT). Comparisons between groups (a) were done with Wilcxon signed rank tests. (b-g) Each point represents a certain follow-up with simultaneously collected blood sample. Each line represents a single patient. The correlation coefficient (rrm) indicate the resultant (overall) direction of intra-individual correlation. Abbreviations: 4-W; 4 weeks follow-up after HT; 6-M, 6 months follow-up after HT; 1-Y, 1 year follow-up after HT; CI, cardiac index; mPAP, mean pulmonary arterial pressure; MRAP, mean right atrial pressure; PAC, pulmonary arterial compliance; PAWP, pulmonary arterial wedge pressure; PVR, pulmonary vascular resistance; Pre-HT, prior to HT; VEGF-D, vascular endothelial growth factor D; WU, wood units. ***p-value < 0.001; **p-value < 0.01, *p-value < 0.05. False discovery rate (Q = 1%) was applied on all comparisons, excluding comparisons indicated with red asterisk (posthoc analysis) in which a p-value of 0.05 was considered statistically significant.

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  Figure 3. Plasma sFlt-1 levels (a), and (b-g) repeated measures correlation analyses with multiple hemodynamic parameters before and at multiple follow-ups after heart transplantation (HT). Comparisons between groups (a) were done with Wilcxon signed rank tests. (b-g) Each point represents a certain follow-up with simultaneously collected blood sample. Each line represents a single patient. The correlation coefficient (rrm) indicates the resultant (overall) direction of intra-individual correlation. Abbreviations: 4-W, 4 weeks follow-up after HT; 6-M, 6 months follow-up after HT; 1-Y, 1 year follow-up after HT; CI, cardiac index; mPAP, mean pulmonary arterial pressure; MRAP, mean right atrial pressure; PAC, pulmonary arterial compliance; PAWP, pulmonary arterial wedge pressure; Pre-HT, prior to HT; PVR, pulmonary vascular resistance; sFlt-1, soluble fms-like tyrosine kinase-1; WU, wood units. ***p-value < 0.001; **p-value < 0.01, *p-value < 0.05. False discovery rate (Q = 1%) was applied on all comparisons, excluding comparisons indicated with red asterisk (posthoc analysis) in which a p-value of 0.05 was considered statistically significant.