Why the study?
Are haemostatic and inflammatory biomarkers elevated in advanced CHF, and are they modified by oral anticoagulants or heart transplantation?
Population
25 patients with advanced chronic heart failure and 25 age- and sex-matched healthy controls.
Comparison
Oral anticoagulants and heart transplantation vs Healthy controls and CHF patients not treated…
Design
Cohort
Authors
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Persistent elevations in advanced CHF despite OAT or transplantation should not yet change practice; hypothesis-generating for targeted trials.
Are haemostatic and inflammatory biomarkers elevated in advanced CHF, and are they modified by oral anticoagulants or heart transplantation?
Advanced CHF is associated with coagulation activation and inflammation that are partially mitigated by oral anticoagulants and heart transplantation but do not fully normalize.
Cugno et al. (2004) studied this question.
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