What question did this study set out to answer?

To evaluate whether provirus load in breast milk predicts the risk of mother-to-child transmission of human T lymphotropic virus type I (HTLV-I).

September 13, 2004The Journal of Infectious DiseasesOpen Access

Provirus Load in Breast Milk and Risk of Mother‐to‐Child Transmission of Human T Lymphotropic Virus Type I

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To evaluate whether provirus load in breast milk predicts the risk of mother-to-child transmission of human T lymphotropic virus type I (HTLV-I).
Prospective cohort study of 101 mother-child pairs conducted in Jamaica.
Measured HTLV-I provirus load in maternal breast milk samples and monitored infant infection status via serologic testing over follow-up.
Provirus load in breast milk was an independent predictor of transmission, with an adjusted relative risk of 2.34 per quartile.
Transmission incidence increased from 4.7 per 1,000 person-months at a provirus load <0.18% to 28.7 per 1,000 person-months at >1.5%.
Detection of provirus in breast milk predicted transmission several months before infant infection was confirmed by serologic testing.

Authors

HLHongchuan LiNational Cancer Institute RBRobert J. BiggarNational Institutes of Health WMWendell MileyFrederick National Laboratory for Cancer Research

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Implication

Prospective study reveals elevated transmission risk in breastfed infants with high milk provirus load, indicating maternal viral burden drives HTLV-I infection.

Cite This Study

Li et al. (2004) studied this question.

synapsesocial.com/papers/6a95ce81acb28a1a8de6ca8b https://doi.org/10.1086/423941

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Implication

Prospective study reveals elevated transmission risk in breastfed infants with high milk provirus load, indicating maternal viral burden drives HTLV-I infection.

Provirus Load in Breast Milk and Risk of Mother‐to‐Child Transmission of Human T Lymphotropic Virus Type I

Key Points

Discussion

Implication

Cite This Study

Provirus Load in Breast Milk and Risk of Mother‐to‐Child Transmission of Human T Lymphotropic Virus Type I

Key Points

Discussion

Implication

Cite This Study

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