What question did this study set out to answer?

To determine whether maternal tuberculosis during pregnancy and through 12 months postpartum increases the risk of mother-to-child transmission of HIV.

January 26, 2011The Journal of Infectious Diseases

Maternal Tuberculosis: A Risk Factor for Mother-to-Child Transmission of Human Immunodeficiency Virus

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To determine whether maternal tuberculosis during pregnancy and through 12 months postpartum increases the risk of mother-to-child transmission of HIV.
Evaluated 783 HIV-infected Indian mother-infant pairs participating in randomized and ancillary cohorts of the Six Week Extended-Dose Nevirapine (SWEN) Study.
Used multivariable logistic regression to measure the association of maternal TB during pregnancy through 12 months postpartum with MTCT, adjusting for maternal and infant factors.
HIV transmission occurred in 10 of 33 mothers with TB (30%) compared with 87 of 750 mothers without TB (12%; OR, 3.31; 95% CI, 1.53–7.29; P = .02).
Maternal TB remained independently associated with increased HIV transmission after multivariable adjustment for maternal viral load, CD4 count, antiretroviral use, and infant factors (adjusted OR, 2.51; 95% CI, 1.05–6.02; P = .04).

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Implication

Randomized trial demonstrates maternal tuberculosis increases mother-to-child HIV transmission risk in breast-fed infants, highlighting the need for maternal tuberculosis prevention.

Cite This Study

Gupta et al. (2011) studied this question.

synapsesocial.com/papers/6a9802bc476dc9b054d7d538 https://doi.org/10.1093/jinfdis/jiq064

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Implication

Randomized trial demonstrates maternal tuberculosis increases mother-to-child HIV transmission risk in breast-fed infants, highlighting the need for maternal tuberculosis prevention.

Maternal Tuberculosis: A Risk Factor for Mother-to-Child Transmission of Human Immunodeficiency Virus

Key Points

Discussion

Implication

Cite This Study

Maternal Tuberculosis: A Risk Factor for Mother-to-Child Transmission of Human Immunodeficiency Virus

Key Points

Discussion

Implication

Cite This Study

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