Key result
Brief episodes of repetitive myocardial ischemia in a mouse model promoted the growth of large coronary arteries and microvasculature, improving perfusion and protecting from subsequent infarction.
Population
Mouse model of myocardial ischemia (closed-chest model)
Design
Preclinical
Authors
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Should not change practice; leaves open whether repetitive ischemia induces coronary angiogenesis in humans.
Repetitive myocardial ischemia in a novel mouse model promotes coronary angiogenesis and protects against subsequent infarction, potentially mediated by cardiac macrophages.
Lavine et al. (2013) studied Myocardial ischemia. Repetitive myocardial ischemia was evaluated on Coronary arterial and microvascular growth. Brief episodes of repetitive myocardial ischemia in a mouse model promoted the growth of large coronary arteries and microvasculature, improving perfusion and protecting from subsequent infarction.
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