Population
Pigs (experimental models of myocardial stunning and chronic coronary artery occlusion)
Comparison
Myocardial stunning and chronic coronary artery… vs Control/normal myocardium
Design
Preclinical
Authors
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Ischemia-driven gene expression may identify collateralization targets; hypothesis-generating in animals and leaves open human translation.
Myocardial ischemia stimulates the expression of transcription factors and growth factors that may play a role in developing collateral circulation.
Sharma et al. (1992) studied this question.
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