December 1, 2002Cardiovascular ResearchOpen Access

Biochemical mechanisms of hibernation and stunning in the human heart

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Population

19 patients undergoing coronary bypass surgery, providing left ventricular transmural myocardial biopsies…

Design

Cross-sectional

Authors

HLHartmut LüssUniversity Hospital Münster

Discussion

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Implication

Distinct cAMP and Hsp72 profiles support mechanistic differences between hibernation and stunning; hypothesis-generating and should not yet change practice.

Structured PICO

Population

19 patients undergoing coronary bypass surgery, providing left ventricular transmural myocardial biopsies from normal (n=19) and dysfunctional segments classified as hibernating (n=10) or stunned (n=9).

Comparator

Biopsies from normal myocardial segments in the same patients (n=19)

Outcome

Levels of cAMP and protein expression of phospholamban, SERCA2a, calsequestrin, troponin inhibitory subunit, p38 MAP kinase activation, and Hsp72surrogate

Myocardial hibernation and stunning exhibit distinct biochemical profiles in humans, with elevated cAMP in hibernation and increased Hsp72 in stunning.

Cite This Study

Hartmut Lüss (2002) studied this question.

synapsesocial.com/papers/6a82b71c57df60cfb510bbc1 https://doi.org/10.1016/s0008-6363(02)00596-5

Topics

Women and heart disease

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Implication

Distinct cAMP and Hsp72 profiles support mechanistic differences between hibernation and stunning; hypothesis-generating and should not yet change practice.

Biochemical mechanisms of hibernation and stunning in the human heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Biochemical mechanisms of hibernation and stunning in the human heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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