Expression of calcium regulatory proteins in short-term hibernation and stunning in the in situ porcine heart1
Why the study?
Does altered expression of calcium regulatory proteins underlie contractile dysfunction in short-term hibernation and stunning in a porcine model?
Population
Enflurane-anaesthetised swine
Comparison
Decreased coronary blood flow through the left… vs Baseline/control values
Design
Preclinical
Follow-up
210 minutes (90 min ischaemia + 120 min reperfusion)
Authors
Discussion
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Member takes
Implication
Does not implicate altered calcium protein expression in porcine stunning/hibernation; leaves open alternative mechanisms.
Structured PICO
Does altered expression of calcium regulatory proteins underlie contractile dysfunction in short-term hibernation and stunning in a porcine model?
P
Population
Enflurane-anaesthetised swine
I
Intervention
Decreased coronary blood flow through the left anterior descending coronary artery to reduce regional contractile function by approximately 50% (90 min ischaemia followed by 120 min reperfusion)
C
Comparator
Baseline/control values
O
Outcome
Expression of sarcoplasmic reticulum calcium ATPase (SERCA), phospholamban (PLB), calsequestrin (CSQ), and troponin inhibitor (TnI) proteins and mRNAssurrogate
Contractile dysfunction during acute ischemia, short-term hibernation, and stunning in a porcine model is not caused by altered expression of key calcium regulatory proteins.
Cite This Study
Lüss et al. (1998) studied this question.