Population
Pig models of stunned (24 hours; n=6) and hibernating (2 weeks; n=6) myocardium, and sham controls (n=7)
Comparison
Induction of stunned or hibernating myocardium… vs Sham control pigs and normal remote…
Design
Preclinical, blinded analysis of samples
Follow-up
Up to 2 weeks
Authors
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Rapid preload elevation reorganizes cytoskeletal proteins in animal hibernating myocardium; leaves open whether this drives human viable dysfunction or warrants preload-targeted trials.
Reorganization of cytoskeletal proteins in viable dysfunctional myocardium occurs rapidly and appears to reflect chronic or cyclical elevations in preload rather than ischemia alone.
Thijssen et al. (2004) studied this question.
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