Key result
Alfentanil (7 µg/kg) plus methohexitone and air/oxygen prevented peroperative blood pressure increases and significantly shortened the awakening phase compared to thiopentone plus N2O/O2.
Why the study?
Does alfentanil plus methohexitone improve recovery and hemodynamics compared to thiopentone plus N2O/O2 in patients undergoing short gynecological surgery?
Population
89 patients undergoing outpatient gynecological surgery
Comparison
Alfentanil plus methohexitone plus O2/air vs Thiopentone 5 mg/kg plus N2O/O2
Design
RCT, randomly allocated to three groups
Follow-up
up to the day after surgery
Authors
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Supports alfentanil-methohexitone for stable hemodynamics and faster recovery in short gynecological surgery; extends RCT evidence on opioid-barbiturate regimens.
RCT (n=89)
randomly allocated
Does alfentanil plus methohexitone improve recovery and hemodynamics compared to thiopentone plus N2O/O2 in patients undergoing short gynecological surgery?
Alfentanil 7 micrograms/kg combined with methohexitone and air/oxygen provides stable hemodynamics and faster awakening for short gynecological procedures compared to thiopentone and N2O/O2.
Bernstein et al. (1989) conducted an RCT in outpatient gynecological surgery (n=89). Alfentanil plus methohexitone and O2/air vs. Thiopentone 5 mg/kg plus N2O/O2 was evaluated on Blood pressure, heart rate, apnea, awakening phase, and postoperative complications. Alfentanil (7 µg/kg) plus methohexitone and air/oxygen prevented peroperative blood pressure increases and significantly shortened the awakening phase compared to thiopentone plus N2O/O2.
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