Key result
Malignancy (OR 4.262; 95% CI 2.263-8.027) and pulmonary circulation disease (OR 28.717) were independent risk factors for VTE in ICH patients, and anticoagulation was associated with higher survival.
Why the study?
Venous thromboembolism is a common complication of intracerebral hemorrhage in ICU patients, but anticoagulation therapy in this setting remains controversial.
Does anticoagulation therapy improve survival in ICU patients with intracerebral hemorrhage and venous thromboembolism?
Population
848 ICU patients with intracerebral hemorrhage
Comparison
Anticoagulation vs non-anticoagulation in patients with VTE
Design
Retrospective database cohort study
Follow-up
Up to 4-year after admission
Authors
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Anticoagulation may be associated with better survival in ICU ICH-VTE patients; hypothesis-generating and requires randomized confirmation before practice change.
Cohort (n=848)
Does anticoagulation therapy improve survival in ICU patients with intracerebral hemorrhage and venous thromboembolism?
Odds Ratio: 4.262 (95% CI 2.263–8.027)
p-value: p=0.000
In ICU patients with intracerebral hemorrhage and VTE, anticoagulation therapy may be safe and associated with improved long-term survival.
Chu et al. (2021) conducted a cohort in Intracerebral hemorrhage (ICH) and venous thromboembolism (VTE) (n=848). Malignancy vs. No malignancy was evaluated on Venous thromboembolism (VTE) (OR 4.262, 95% CI 2.263-8.027, p=0.000). Malignancy (OR 4.262; 95% CI 2.263-8.027) and pulmonary circulation disease (OR 28.717) were independent risk factors for VTE in ICH patients, and anticoagulation was associated with higher survival.