Key result
Phenytoin was successfully used to treat polymorphic ventricular tachycardia due to QT prolongation in a patient with multiple antiarrhythmic drug intolerances.
Case Report (n=1)
Phenytoin may serve as a potent and useful antiarrhythmic agent for treating ventricular tachycardia in patients with multiple drug intolerances.
Phenytoin may be considered in select intolerant patients with QT-related polymorphic VT; hypothesis-generating and requires prospective validation.
We present a case of a 69-year-old woman presenting with polymorphic ventricular tachycardia caused by QT prolongation. Owing to known intolerances to a majority of antiarrhythmic medications, one remaining option was to initiate phenytoin. Phenytoin's narrow therapeutic window, multiple drug interactions and side effect profile make it an infrequently used antiarrhythmic. It is, however, a potent antiarrhythmic agent, which may be useful in treatment of ventricular tachycardia, especially in patients with multiple drug intolerances.
No takes yet. Share an insight, caveat, or question.
Yager et al. (2015) conducted a case report in Polymorphic ventricular tachycardia caused by QT prolongation (n=1). Phenytoin was evaluated. Phenytoin was successfully used to treat polymorphic ventricular tachycardia due to QT prolongation in a patient with multiple antiarrhythmic drug intolerances.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: