Long-term mortality and vascular event risk after aneurysmal subarachnoid haemorrhage
Key result
Patients recovering from subarachnoid hemorrhage had excess mortality compared to the general population (SMR 1.7) but a lower 10-year risk of vascular events than those with minor stroke (HR 0.43).
Why the study?
Are patients who recover from aneurysmal subarachnoid haemorrhage at increased risk for long-term mortality and vascular events compared to the general population or patients with minor stroke?
Population
752 patients clipped between 1985 and 2001 after aneurysmal subarachnoid haemorrhage who had been discharged…
Design
Cohort
Follow-up
mean 8.1 years
Authors
Discussion
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Implication
Excess mortality after subarachnoid hemorrhage recovery warrants surveillance; leaves open whether vascular prevention differs from minor stroke.
Study Design
Type
Cohort (n=752)
Structured PICO
Are patients who recover from aneurysmal subarachnoid haemorrhage at increased risk for long-term mortality and vascular events compared to the general population or patients with minor stroke?
P
Population
752 patients (mean age 50 years, 67% women) clipped between 1985 and 2001 after SAH who had been discharged home or to a rehabilitation facility, followed for a mean of 8.1 years.
C
Comparator
General population (for mortality) and patients after a transient ischaemic attack or minor stroke (for vascular events)
O
Outcome
Age- and sex-specific mortality (standardised mortality ratios) and incidence of new vascular eventshard clinical
Main Result
Hazard Ratio: 0.43 (95% CI 0.33–0.57)
Patients who recover to a functionally independent state after aneurysmal subarachnoid hemorrhage still face excess long-term mortality and a notable risk of vascular events.
Cite This Study
Wermer et al. (2009) conducted a cohort in Aneurysmal subarachnoid haemorrhage (n=752). History of aneurysmal subarachnoid haemorrhage vs. General population and patients with minor stroke was evaluated on Vascular events compared to patients with a minor stroke (HR 0.43, 95% CI 0.33 to 0.57). Patients recovering from subarachnoid hemorrhage had excess mortality compared to the general population (SMR 1.7) but a lower 10-year risk of vascular events than those with minor stroke (HR 0.43).