Key result
Beating-heart CABG with M-CPB resulted in significantly more complete coronary revascularization compared to OPCAB among 124 propensity-matched patients, with comparable hospital mortality.
Why the study?
Does beating-heart CABG with miniaturized cardiopulmonary bypass improve complete revascularization and hospital mortality compared to off-pump CABG in patients undergoing surgical revascularization?
Cohort (n=302)
Does beating-heart CABG with miniaturized cardiopulmonary bypass improve complete revascularization and hospital mortality compared to off-pump CABG in patients undergoing surgical revascularization?
Beating-heart CABG with miniaturized cardiopulmonary bypass facilitates more complete coronary revascularization compared to off-pump CABG without increasing hospital mortality.
May support M-CPB for more complete revascularization in beating-heart CABG; hypothesis-generating and requires randomized confirmation.
The technique of miniaturized cardiopulmonary bypass (M-CPB) for beating-heart coronary artery bypass grafting (CABG) is relatively new and has potential advantages when compared to conventional cardiopulmonary bypass (CPB). M-CPB consists of less tubing length and requires less priming volume. The system is phosphorylcholine coated and results in minimal pump-related inflammatory response and organ injury. Finally, this technique combines the advantages of the off-pump CABG (OPCAB) with the better exposure provided by CPB to facilitate complete revascularization. The hypothesis is that CABG with M-CPB has a better outcome in terms of complete coronary revascularization and perioperative results as that compared to off-pump CABG (OPCAB). In a retrospective study, 302 patients underwent beating-heart CABG, 117 (39%) of them with the use of M-CPB and 185 (61%) with OPCAB. After propensity score matching 62 patients in both groups were demographically similar. The most important intra- and early-postoperative parameters were analyzed. Endpoints were hospital mortality and complete revascularization. Hospital mortality was comparable between the groups. The revascularization was significantly more complete in M-CPB patients than in patients in the OPCAB group. Beating-heart CABG with M-CPB is a safe procedure and it provides an optimal operative exposure with significantly more complete coronary revascularization when compared to OPCAB. Beating-heart CABG with the support of a M-CPB is the operation of choice when total coronary revascularization is needed.
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Reber et al. (2010) conducted a cohort in Coronary artery disease requiring CABG (n=302). Beating-heart CABG with miniaturized cardiopulmonary bypass (M-CPB) vs. Off-pump CABG (OPCAB) was evaluated on Hospital mortality and complete revascularization. Beating-heart CABG with M-CPB resulted in significantly more complete coronary revascularization compared to OPCAB among 124 propensity-matched patients, with comparable hospital mortality.
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