Key result
First-trimester 3-dimensional power Doppler indices of the uteroplacental circulation space predicted the development of preeclampsia with an area under the curve of up to 79.6%.
Why the study?
Does first-trimester 3-dimensional power Doppler of the uteroplacental circulation space predict the development of preeclampsia in singleton pregnancies?
Observational (n=277)
Does first-trimester 3-dimensional power Doppler of the uteroplacental circulation space predict the development of preeclampsia in singleton pregnancies?
Effect estimate: AUC 78.9%, 77.6%, and 79.6% for VI, FI, and VFI
First-trimester 3-dimensional power Doppler indices of the uteroplacental circulation space are lower in women who develop preeclampsia and show potential as a predictive screening tool.
May support early preeclampsia risk stratification; leaves open prospective validation before clinical screening use.
OBJECTIVE: The objective of the study was to compare 3-dimensional power Doppler (3DPD) of the uteroplacental circulation space (UPCS) in the first trimester between women who develop preeclampsia (PEC) and those who do not and to assess the 3DPD method as a screening tool for PEC. STUDY DESIGN: This was a prospective observational study of singleton pregnancies at 10 weeks 4 days to 13 weeks 6 days. The 3DPD indices, vascularization index (VI), flow index (FI), and vascularization flow index (VFI), were determined on a UPSC sphere biopsy with the virtual organ computer-aided analysis (VOCAL) program. RESULTS: Of 277 women enrolled, 24 developed PEC. The 3DPD indices were lower in women who developed PEC. The area under the receiver-operating characteristics curve for the prediction of PEC was 78.9%, 77.6%, and 79.6% for VI, FI, and VFI, respectively. CONCLUSION: Patients who develop PEC have lower 3DPD indices of their UPCS during the first trimester. Our findings suggest that this ultrasonographic tool has the potential to predict the development of PEC.
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Dar et al. (2010) conducted an observational in Preeclampsia (n=277). 3-dimensional power Doppler (3DPD) of the uteroplacental circulation space was evaluated on Prediction of preeclampsia (AUC 78.9%, 77.6%, and 79.6% for VI, FI, and VFI). First-trimester 3-dimensional power Doppler indices of the uteroplacental circulation space predicted the development of preeclampsia with an area under the curve of up to 79.6%.
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