Key result
A combination of placental 3D power Doppler ultrasonography parameters (vascularization index, flow index, and vascularization flow index) significantly predicted poor pregnancy outcomes in patients with hypertensive disorders complicating pregnancy with an AUC of 0.75.
Why the study?
The study aimed to compare placental 3D power Doppler ultrasonography parameters in late pregnancy between patients with and without HDCP, and to evaluate their predictive value for pregnancy outcomes in HDCP.
Does placental 3D power Doppler ultrasonography predict adverse pregnancy outcomes in women with hypertensive disorders complicating pregnancy?
Observational (n=260)
Single-blind
No
Does placental 3D power Doppler ultrasonography predict adverse pregnancy outcomes in women with hypertensive disorders complicating pregnancy?
Effect estimate: AUC 0.75 (95% CI 0.68-0.83)
p-value: p=<0.001
Placental 3D power Doppler ultrasonography parameters are significantly reduced in hypertensive disorders of pregnancy and their combination can predict adverse pregnancy outcomes.
May support placental perfusion monitoring in HDCP; observational data leave clinical utility for outcome prediction open.
Hypertensive disorders complicating pregnancy (HDCP) represent a systemic condition specific to pregnant women. Three-dimensional (3D) power Doppler ultrasonography is a technique that utilizes erythrocyte density, scattered intensity, or energy distribution in the bloodstream for imaging purposes. This study aimed to compare the changes in 3D power Doppler ultrasonography parameters in late pregnancy between patients with HDCP and those without HDCP, and to evaluate the predictive value of these parameters for pregnancy outcomes in patients with HDCP. The study included 160 pregnant women diagnosed with HDCP and 100 pregnant women without HDCP, who served as the control group. 3D power Doppler ultrasonography was performed, and the values of the vascularization index (VI), flow index (FI), and vascularization flow index (VFI) were measured. In the HDCP group, the VI, FI, and VFI were all lower than those observed in patients without HDCP. In HDCP patients with positive outcomes, these three parameters were higher than those recorded in patients with negative outcomes. The area under the predicted curve (AUC) for VI, FI, VFI, and the combination of these three parameters were 0.69, 0.63, 0.66, and 0.75, respectively. The parameters of 3D power Doppler ultrasonography can reflect the perfusion status of the placenta and predict the outcome of pregnancy in patients with HDCP. By monitoring these relevant hemodynamic parameters, valuable information can be provided for the clinical diagnosis, objective evaluation, and treatment of HDCP.
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Liu et al. (2023) conducted an observational in Hypertensive disorders complicating pregnancy (HDCP) (n=260). Placental 3D power Doppler ultrasonography parameters (VI, FI, VFI) was evaluated on Prediction of poor pregnancy outcomes using a combination of vascularization index (VI), flow index (FI), and vascularization flow index (VFI) (AUC 0.75, 95% CI 0.68-0.83, p=<0.001). A combination of placental 3D power Doppler ultrasonography parameters (vascularization index, flow index, and vascularization flow index) significantly predicted poor pregnancy outcomes in patients with hypertensive disorders complicating pregnancy with an AUC of 0.75.
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