Why the study?
Mitochondrial diseases feature nitric oxide deficiency leading to endothelial dysfunction and microvascular hypoperfusion, and the effect of supplementing nitric oxide precursors arginine and citrulline required investigation.
Does arginine or citrulline supplementation improve reactive hyperemic index in children and adolescents with mitochondrial diseases?
Population
Children and adolescents with mitochondrial diseases
Comparison
Arginine and citrulline supplementation
Key result
Arginine or citrulline supplementation increased the reactive hyperemic index, indicating improved endothelial dysfunction in children and adolescents with mitochondrial diseases.
Authors
Loading...
May support arginine or citrulline for endothelial dysfunction in mitochondrial disease; hypothesis-generating and requires randomized confirmation before practice change.
Does arginine or citrulline supplementation improve reactive hyperemic index in children and adolescents with mitochondrial diseases?
Arginine or citrulline supplementation may improve endothelial dysfunction in children and adolescents with mitochondrial diseases by enhancing nitric oxide production.
Jasmi et al. (2020) studied Mitochondrial diseases. Arginine and citrulline supplementation was evaluated on Reactive hyperemic index (RHI). Arginine or citrulline supplementation increased the reactive hyperemic index, indicating improved endothelial dysfunction in children and adolescents with mitochondrial diseases.