Extended-spectrum cephalosporins (ESC) are an important drug class for treating severe Salmonella infections. We screened the human collection from the National Antimicrobial Resistance Monitoring System 2000 for ESC resistance mechanisms. Of non-Typhi Salmonella tested, 3.2% (44/1,378) contained bla CMY genes. Novel findings included bla CMY -positive Escherichia coli O157:H7 and a bla SHV -positive Salmonella isolate. CMY-positive isolates showed a ceftriaxone MIC >2 g/mL. E xtended-spectrum cephalosporins (ESC) are important for treating persons with severe Salmonella infections (1). This drug class is particularly important for pediatric therapy because fluoroquinolones are not approved for use in children. In 2000, 25% (8,153/32,022) of laboratoryconfirmed Salmonella cases reported to the Centers for Disease Control and Prevention (CDC) occurred in children <5 years of age (2).
No takes yet. Share an insight, caveat, or question.
Whichard et al. (2005) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: