Key result
In obese patients with postoperative atrial fibrillation, epicardial adipose tissue with inflammation had higher GHS-R expression (9.4 vs 6.0 No/µm2) and larger adipocytes than tissue without inflammation.
Why the study?
Obesity causes adipose tissue inflammation, which is linked to AF, and ghrelin receptor signaling on adipose tissue macrophages may modulate this inflammation.
Observational (n=10)
No
Absolute Event Rate: 9.4% vs 6%
Increased macrophage infiltration and GHS-R expression in epicardial adipose tissue are associated with postoperative atrial fibrillation in obese patients.
May link epicardial adipose inflammation to postoperative AF in obese patients; hypothesis-generating and should not change practice.
CONTEXT: Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice. The increasing evidence supports links between inflammation and AF. There is evidence showing that obesity is a major cause of adipose tissue (AT) inflammation. Ghrelin (GHRL), through its growth hormone secretagogue receptor (GHS-R) present on adipose tissue macrophages (ATMs), could modulate AT inflammation. OBJECTIVE: Our study aimed to evaluate the role of adipose tissue macrophages (ATMs) and their GHS-R in adipose tissue samples of right atrial appendages (RAA) biopsies. SUBJECTS AND METHOD: We obtained RAA biopsies from 10 obese patients, undergoing cardiac surgery for coronary artery bypass graft (CABG) and developing postoperative atrial fibrillation (POAF). The epicardial tissue samples were examined using immunohistochemistry to visualize and quantify CD68 and GSH-R expression of the ATMs. RESULTS: . 79.6 µm). The expression of CD68 was lower in EAT without inflammation as compared to EAT with inflammation in adipose tissue samples. Similarly, the expression of GSH-R was lower in EAT samples without inflammation as compared to EAT samples with inflammation in adipose tissue. CONCLUSIONS: Increased epicardial fat area, macrophage infiltration, and GHS-R expression in epicardial ATMs appeared to be associated with postoperative atrial fibrillation in obese patients.
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Veronica Mocanu (2020) conducted an observational in Postoperative atrial fibrillation in obese patients (n=10). Epicardial adipose tissue inflammation vs. Epicardial adipose tissue without inflammation was evaluated on GHS-R expression (No/µm2). In obese patients with postoperative atrial fibrillation, epicardial adipose tissue with inflammation had higher GHS-R expression (9.4 vs 6.0 No/µm2) and larger adipocytes than tissue without inflammation.
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