Why the study?
Increased macrophage GHSR expression promotes meta-inflammation in obesity, but its association with atherosclerotic plaques and adjacent PVAT in obese patients required investigation.
Population
11 patients with obesity and PAD undergoing revascularization procedures
Comparison
GHSR-1a-positive (+) macrophages vs GHSR-1a-negative in plaques
Design
Observational tissue and serum analysis
Key result
GHSR-1a-positive macrophages in atherosclerotic plaques were associated with significantly higher WBC counts, elevated IL-6, and lower adiponectin-to-leptin ratios in patients with obesity and PAD.
Authors
Loading...
Hypothesis-generating for GHSR-1a in obese PAD plaque inflammation; prospective studies needed before clinical relevance.
Observational (n=11)
GHSR-1a expression in macrophages is associated with increased inflammation and adipocytokine secretion in atherosclerotic plaques of obese patients with peripheral artery disease.
Peiu et al. (2025) conducted an observational in Obesity and peripheral artery disease (PAD) (n=11). GHSR-1a expression was evaluated on Inflammatory markers and adipocytokine levels (WBC, platelet-to-lymphocyte ratio, adiponectin-to-leptin ratio, IL-6). GHSR-1a-positive macrophages in atherosclerotic plaques were associated with significantly higher WBC counts, elevated IL-6, and lower adiponectin-to-leptin ratios in patients with obesity and PAD.