Key result
Ghrelin exhibits anti-inflammatory effects on adipose tissue macrophage infiltration and inhibits proinflammatory adipokine secretion, highlighting its potential cardioprotective role in atherosclerosis.
Why the study?
The cardioprotective effects of ghrelin appear contradictory to its adipogenic properties, prompting exploration of the anti- and pro-atherogenic mechanisms of ghrelin and perivascular adipose tissue-derived adipokines in atherosclerosis progression.
Ghrelin's anti-inflammatory effects on perivascular adipose tissue may play a protective role against atherosclerosis progression, suggesting a need to study its impact on endothelial function in relation to PVAT.
Ghrelin effects on PVAT inflammation remain preclinical; leaves open therapeutic impact on atherosclerosis or endothelial function.
Perivascular adipose tissue (PVAT) and its adipokines engage in bidirectional crosstalk with the vascular wall. Atherosclerosis disrupts this interaction through inflammation, rupture-prone plaques, and subsequent thrombosis. The cardioprotective effects of ghrelin are in contradiction to its adipogenic properties. The concurrent research of anti-/pro-atherogenic mechanisms of ghrelin and PVAT-derived adipokines provides a better understanding of atherosclerosis progression in metabolic disorders. In-depth coverage of the characteristic features of PVAT concerning vascular dysfunction, with a survey of ghrelin-induced anti-inflammatory effects on adipose tissue macrophage infiltration and the inhibitory activity of ghrelin on the proinflammatory adipokine secretion, show that the impact of ghrelin on the endothelial function should be studied in relation to PVAT.
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Peiu et al. (2022) conducted a review in Atherosclerosis. Ghrelin was evaluated. Ghrelin exhibits anti-inflammatory effects on adipose tissue macrophage infiltration and inhibits proinflammatory adipokine secretion, highlighting its potential cardioprotective role in atherosclerosis.
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