Metabolic syndrome: Development of D.D.Pletnev’s and G.F.Lang’s ideas

Metabolic syndrome is a problem of our time due to its high prevalence (from 20 to 50% in the adult population). The aim of the work was to outline the main stages in the study of the totality of hemodynamic and metabolic disorders that was later designated “metabolic syndrome”, in Russia. The article focuses on the development of the ideas of D.D.Pletnev and G.F.Lang from the beginning of the 20th century to the present at the Department of Faculty Therapy in Petrograd Medical Institute for Women, which was later named the First Leningrad Medical Institute and is now named Federal State Budgetary Educational Institution of Higher Education Academician I.P.Pavlov First St. Petersburg State Medical University under the Ministry of Healthcare of Russian Federation. The article discusses current trends in the study of the metabolic syndrome, including data from epidemiological studies on the prevalence of the metabolic syndrome and its individual components in Russia.Results. The paper presents the results of molecular genetic and instrumental methods for examining patients with abdominal obesity, metabolic syndrome, including those with complications such as atrial fibrillation, coronary heart disease, chronic heart failure with preserved left ventricular fraction. The review presents data on the molecular and other features of subcutaneous and visceral (epicardial) adipose tissue.Conclusion. The paper outlines priority areas for studying the metabolic syndrome in the future, which will be important for preventing the development and progression of this pathological condition.