Key result
Fulminant myocarditis in children was associated with significant differential expression of circRNAs, including a 2.5-fold upregulation of hsa_circ_0071542 compared to healthy volunteers.
Why the study?
Differential expression profiles and potential functions of circular RNAs in pediatric fulminant myocarditis had not been determined.
Are there differentially expressed circular RNAs in children with fulminant myocarditis compared to healthy volunteers?
Case-Control (n=6)
Are there differentially expressed circular RNAs in children with fulminant myocarditis compared to healthy volunteers?
hsa_circ_0071542 is significantly upregulated in pediatric fulminant myocarditis and could serve as a promising biomarker.
Answers are grounded in this paper and cite their sources.
circRNA dysregulation is associated with pediatric fulminant myocarditis; leaves open biomarker utility pending prospective validation.
Aim: To assess differential expression profiles of circular RNAs (circRNAs) and explore their possible functions in children with fulminant myocarditis. Materials & methods: circRNA microarray experiments were carried out for determining differential expression profiles of circRNAs in three children with fulminant myocarditis and three healthy volunteers. Functional analysis and circRNA–miRNA–mRNA interaction network building were conducted to study biological functions. Results: This work identified 2281 upregulated and 892 downregulated circRNAs. Further assessment confirmed hsa_circ_0071542 upregulation (2.5-fold) in fulminant myocarditis. Functional analysis demonstrated the differentially expressed circRNAs mainly contributed to inflammation and immunity. Conclusion: circRNAs might have substantial roles in pediatric fulminant myocarditis, and hsa_circ_0071542 could serve as a promising biomarker.
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Zhang et al. (2019) conducted a case-control in fulminant myocarditis (n=6). Fulminant myocarditis vs. Healthy volunteers was evaluated on Differential expression profiles of circRNAs (2.5-fold upregulation). Fulminant myocarditis in children was associated with significant differential expression of circRNAs, including a 2.5-fold upregulation of hsa_circ_0071542 compared to healthy volunteers.
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