Key result
Severe left ventricular hypertrophy was present in 7.3% of hypertensive patients and was associated with more uncontrolled blood pressure compared to patients with normal left ventricular geometry.
Why the study?
Left ventricular hypertrophy is a key prognostic marker and mortality predictor in arterial hypertension, prompting the examination of its echocardiographic prevalence and the characterisation of patients with severe LVH.
What is the prevalence and clinical profile of severe left ventricular hypertrophy detected by echocardiography in patients with arterial hypertension?
Observational (n=400)
No
What is the prevalence and clinical profile of severe left ventricular hypertrophy detected by echocardiography in patients with arterial hypertension?
Answers are grounded in this paper and cite their sources.
Severe left ventricular hypertrophy is present in 7.3% of hypertensive patients and is associated with older age, male sex, and uncontrolled blood pressure despite intensive therapy.
BACKGROUND: Arterial hypertension (AHT) is the leading preventable cause of death worldwide. Left ventricular hypertrophy (LVH) is one of the most important prognostic markers in hypertension and a predictor for mortality. The goals of this study were to examine the prevalence of LVH detected by echocardiography in patients with AHT and to describe patients with severe LVH. METHODS: This is a retrospective monocentric study including patients treated at a tertiary hypertension clinic. Echocardiographic data were taken from written reports from our hospital's echocardiography laboratories. We compared patients with severe LVH (septum thickness ≥ 15 mm) with patients with normal left ventricular (LV) geometry and with patients with concentric or eccentric hypertrophy regarding age, gender, comorbidities, medication, duration of hypertension, blood pressure (BP) and ECG changes at time of echocardiography. RESULTS: Twenty-nine patients (7.3%) out of four hundred patients showed severe LVH and one hundred and eighty-nine (47.3%) a normal geometry. In comparison to patients with normal geometry, patients with severe LVH were more likely to be male, older, and with more uncontrolled BP, especially regarding asleep values, multi-drug antihypertensive treatment and comorbidities. In comparison to patients with concentric or eccentric hypertrophy, patients with severe LVH had a significantly higher diastolic BP in the 24 h mean, awake and asleep values. A positive Sokolow-Lyon index did not predict LVH. However, patients with severe LVH were more likely to have T-wave-inversions V4-V6 in at least one lead. CONCLUSIONS: More than half of the patients with AHT have an abnormal geometry in our study (52.5%) and 7.3% a severe LVH. Patients with severe LVH have more often an uncontrolled AHT than patients with a normal LV geometry, despite more antihypertensive treatment. The Sokolow-Lyon index seems to be insufficient to detect LVH.
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Apitz et al. (2022) conducted an observational in Arterial hypertension (n=400). Severe left ventricular hypertrophy (septum thickness ≥ 15 mm) vs. Normal left ventricular geometry or concentric/eccentric hypertrophy was evaluated on Prevalence of severe left ventricular hypertrophy. Severe left ventricular hypertrophy was present in 7.3% of hypertensive patients and was associated with more uncontrolled blood pressure compared to patients with normal left ventricular geometry.
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