Key result
Concentric and eccentric left ventricular hypertrophy in essential hypertension patients were associated with higher overall mortality (37% and 35%) compared to normal LV geometry (20%).
Why the study?
Does the type of left ventricular hypertrophy (concentric vs eccentric) affect overall mortality in patients with essential hypertension compared to normal left ventricular geometry?
Cohort (n=491)
Does the type of left ventricular hypertrophy (concentric vs eccentric) affect overall mortality in patients with essential hypertension compared to normal left ventricular geometry?
Answers are grounded in this paper and cite their sources.
Both concentric and eccentric LVH significantly increase 5-year mortality in hypertensive patients compared to normal LV geometry, with left atrial enlargement acting as a universal marker of poor outcome.
Left ventricular hypertrophy (LVH) is the most important element of cardiovascular continuum in patients with essential hypertension (EH). The results of a five-year retrospective analysis of EH patients cohort with initially different types of left ventricular geometry (491 subjects) are presented. It is shown that the overall mortality in patients with concentric and eccentric LVH does not differ significantly (37 and 35 %, respectively) but exceeds that in subjects with normal LV geometry (20 %). Associated and concomitant pathology determine the total and cardiovascular prognosis more in patients with concentric LVH than in subjects with eccentric LVH. The presence of ECG valid quantitative and strain diagnostic LVH criteria (Sokolow-Lyon index and Perugian university sign) determines the worst remote prognosis in patients with both concentric and eccentric LVH. The enlarged size of the left atrium is an universal marker of poor outcome in hypertensive patients regardless the type оf left ventricular geometry.
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Барсуков et al. (2012) conducted a cohort in Essential hypertension (n=491). Left ventricular hypertrophy (concentric and eccentric) vs. Normal left ventricular geometry was evaluated on Overall mortality. Concentric and eccentric left ventricular hypertrophy in essential hypertension patients were associated with higher overall mortality (37% and 35%) compared to normal LV geometry (20%).
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