Population
Colorectal cancer (CRC) cells and patients with advanced CRC
Design
Preclinical
Key result
Interaction between hepatic angiopoietin-like 6 and tumoural α6 integrin/E-cadherin drives liver metastasis by colorectal cancer cells, with high coexpression indicating poor prognosis.
Authors
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Hypothesis-generating for targeting angiopoietin-like 6 in CRC metastasis; clinical validation in humans is required before any practice change.
Identification of a specific ligand-receptor interaction driving CRC liver metastasis provides a potential therapeutic target and prognostic biomarker.
Marchiò et al. (2012) studied Colorectal cancer. α6 integrin and E-cadherin coexpression was evaluated on Liver metastasis and prognosis. Interaction between hepatic angiopoietin-like 6 and tumoural α6 integrin/E-cadherin drives liver metastasis by colorectal cancer cells, with high coexpression indicating poor prognosis.