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June 3, 2026Clinical and Experimental MedicineOpen Access

Exosomal integrin αvβ3 derived from colorectal cancer promotes the liver pre-metastatic niche formation by inducing cancer-associated fibroblasts activation

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Authors

JYJing YuJXJiangning XiangYLYao Lin

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Overview

Randomized trial reveals how exosomal integrin αvβ3 activates HSCs to form the liver PMN, indicating new intervention strategies for CRLM.

Key Points

  • This research aims to elucidate the role of exosomal integrin αvβ3 in the activation of hepatic stellate cells leading to the liver pre-metastatic niche formation in colorectal cancer liver metastasis.
  • Investigated the association between exosomal integrin αvβ3 and colorectal cancer liver metastasis.
  • Examined targeted effects on hepatic stellate cells via fibronectin.
  • Explored the MEK-ERK signaling pathway activation through the vitronectin-Integrin αvβ3-FAK axis.
  • Exosomal integrin αvβ3 significantly activates hepatic stellate cells (HSCs).
  • Activated HSCs differentiate into cancer-associated fibroblasts (CAFs), promoting liver pre-metastatic niche (PMN) development.
  • This process involves epithelial-mesenchymal transition (EMT), angiogenesis, and inflammatory factor mediation.

Cite This Study

Yu et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc6f7dee9eb8c0dce7e12https://doi.org/10.1007/s10238-026-02193-5
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