Key result
Stratification of intermediate-risk pulmonary arterial hypertension patients using six-minute walk distance and TAPSE/sPAP ratio identified a subset with mortality comparable to low-risk patients.
Why the study?
Does further stratification based on six-minute walk distance and TAPSE/sPAP ratio improve risk prediction for mortality in intermediate-risk treatment-naïve patients with pulmonary arterial hypertension?
Observational (n=301)
Does further stratification based on six-minute walk distance and TAPSE/sPAP ratio improve risk prediction for mortality in intermediate-risk treatment-naïve patients with pulmonary arterial hypertension?
Combining six-minute walk distance and TAPSE/sPAP ratio can identify a lower-risk subset among intermediate-risk PAH patients, potentially refining prognosis and treatment strategies.
May identify lower-risk intermediate PAH subsets; hypothesis-generating and requires prospective validation before guiding therapy.
In 301 treatment-naïve patients with pulmonary arterial hypertension stratified by the European Society of Cardiology/European Respiratory Society risk score, further stratification of intermediate-risk patients based on six-minute walk distance and the tricuspid annular plane systolic excursion/systolic pulmonary artery pressure ratio identified a subset with mortality rates comparable to low-risk patients.
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Yogeswaran et al. (2020) conducted an observational in Pulmonary arterial hypertension (n=301). Stratification based on six-minute walk distance and TAPSE/sPAP ratio vs. Low-risk patients was evaluated on Mortality. Stratification of intermediate-risk pulmonary arterial hypertension patients using six-minute walk distance and TAPSE/sPAP ratio identified a subset with mortality comparable to low-risk patients.
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