August 19, 2014International Journal of Molecular MedicineOpen Access

Angiopoietin-like protein 2 negatively regulated by microRNA-25 contributes to the malignant progression of colorectal cancer

Q: What is the clinical evidence from this study?

Study design: Other. Population: Colorectal cancer (n=50). Intervention: ANGPTL2 knockdown and miR-25 overexpression vs. Control cells and adjacent normal tissues. Primary outcome: Cell migration, invasion, and colony formation (p=<0.05).

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Key result

ANGPTL2 upregulation, partly induced by miR-25 downregulation, promotes the invasion and migration of colorectal cancer cells.

Population

Colorectal cancer tissues and human CRC cell lines (SW620 and HCT-116)

Comparison

Knockdown of ANGPTL2, overexpression or… vs Control cells

Design

Preclinical

Authors

JZJumei ZhouNingbo University JWJing WangNaval Medical Research Command SWShengqi WuCentral South University

Discussion

Member takes

Implication

May identify ANGPTL2/miR-25 as a metastasis target in colorectal cancer models; leaves open human translation.

Structured PICO

Population

In vitro and ex vivo study utilizing 50 cases of colon adenocarcinoma tissues and human colorectal cancer cell lines to investigate the roles of ANGPTL2 and miR-25.

Intervention

Knockdown of ANGPTL2, overexpression or downregulation of miR-25

Comparator

Control cells

Outcome

Cell migration, invasion, and colony formationsurrogate

Main Result

p-value: p=<0.05

In preclinical models, miR-25 directly targets and downregulates ANGPTL2, thereby reducing the invasive and migratory abilities of colorectal cancer cells.

Cite This Study

Zhou et al. (2014) studied Colorectal cancer (n=50). ANGPTL2 knockdown and miR-25 overexpression vs. Control cells and adjacent normal tissues was evaluated on Cell migration, invasion, and colony formation (p=<0.05). ANGPTL2 upregulation, partly induced by miR-25 downregulation, promotes the invasion and migration of colorectal cancer cells.

synapsesocial.com/papers/6a961f8cc278dbfca3d1bcfa https://doi.org/10.3892/ijmm.2014.1909

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August 19, 2014International Journal of Molecular MedicineOpen Access

Angiopoietin-like protein 2 negatively regulated by microRNA-25 contributes to the malignant progression of colorectal cancer

View Full Paper

Ask AI

Bookmark

Key result

ANGPTL2 upregulation, partly induced by miR-25 downregulation, promotes the invasion and migration of colorectal cancer cells.

Population

Colorectal cancer tissues and human CRC cell lines (SW620 and HCT-116)

Comparison

Knockdown of ANGPTL2, overexpression or… vs Control cells

Design

Preclinical

Authors

JZJumei ZhouNingbo University JWJing WangNaval Medical Research Command SWShengqi WuCentral South University

Discussion

Member takes

Implication

May identify ANGPTL2/miR-25 as a metastasis target in colorectal cancer models; leaves open human translation.

Structured PICO

Population

In vitro and ex vivo study utilizing 50 cases of colon adenocarcinoma tissues and human colorectal cancer cell lines to investigate the roles of ANGPTL2 and miR-25.

Intervention

Knockdown of ANGPTL2, overexpression or downregulation of miR-25

Comparator

Control cells

Outcome

Cell migration, invasion, and colony formationsurrogate

Main Result

p-value: p=<0.05

In preclinical models, miR-25 directly targets and downregulates ANGPTL2, thereby reducing the invasive and migratory abilities of colorectal cancer cells.

Cite This Study

synapsesocial.com/papers/6a961f8cc278dbfca3d1bcfa https://doi.org/10.3892/ijmm.2014.1909

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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