Atomic Force Microscopic Evidence for Z-band as a Rigid Disc Fixing the Sarcomere Structure of Skeletal Muscle.

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Population

Single skeletal myofibrils

Comparison

Treatment with calcium-activated neutral protease vs Intact single myofibrils

Design

Preclinical

Authors

Discussion

Z-bands may confer sarcomere rigidity in isolated myofibrils; leaves open in vivo cardiac relevance.

Population

Single skeletal myofibrils

Intervention

Treatment with calcium-activated neutral protease

Comparator

Intact single myofibrils

Outcome

Presence of narrow rigid bands and structural fragility assessed by atomic force microscopysurrogate

Atomic force microscopy confirms that Z-bands act as essential rigid discs supporting the sarcomere structure of skeletal muscle.

Wakayama et al. (2000) studied this question.

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